It’s a SMAD, SMAD World
نویسندگان
چکیده
منابع مشابه
It’s a SMAD/SMAD World
DPC4/SMAD4 mutations are associated with aggressive pancreatic cancer. In this issue of Cell, Whittle et al. demonstrate that Runx3 expression combined with Dpc4/Smad4 status can predict the metastatic propensity of pancreatic tumors, providing valuable guidance for personalized therapy for patients with pancreatic cancer.
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binding by the ternary Smad–FAST complex. Smad3 can bers are a group of secreted polypeptides that regulate replace Smad2 in this complex and at the Mix.2 element a diverse array of developmental and biological pro-can activate transcription (Yeo et al., 1999), whereas at the cesses. Disruption of the ligands or of components of goosecoid promoter Smad3 blocks activation (Labbé et their signali...
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ژورنال
عنوان ژورنال: JACC: Basic to Translational Science
سال: 2019
ISSN: 2452-302X
DOI: 10.1016/j.jacbts.2019.01.006